Floating Sustained release delivery systems for oral dosing are effective in achieving optimal therapy with drugs that have a narrow therapeutic range of blood concentration which eliminate rapidly. The present work involves use of gastric floating drug delivery system (GFDDS) for Stavudine which is primarily absorbed in the stomach and upper intestine segments. The main objective of the present work was to formulate and evaluate the regiospecific floating tablet of Stavudine. Stavudine gifted sample, Polymers such as HPMC K15M, HPMC K100M and Xanthan gum are selected for the formulation development. Pre formulation studies includes Drug excipient interaction studies were studied using Fourier Transform Infrared and Differential Scanning Calorimetery, developed formulation subjected for all the In-vitro evaluation studies for tablets, floating behavior was studied by In- vitro buoyancy studies, drug release behavior was studied by Kinetic modeling and the best formulation was loaded for stability studies under 40 ºC and 70% RH. From the above studies it was concluded that the formulation F5 showed the sustained drug release profile with good matrix integrity, less floating lag time with good total floating time and higher swelling index as compared with the selected batches. It may be concluded that the floating effervescent tablets of stavudine was feasible and may be manufactured with reproducible characteristics with the aid of HPMC K100M as a hydrophilic polymer.
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